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Oxandrolone is widely used due to its exceptionally small androgenic effect, combined with a moderate anabolic effect. Although oxandrolone is an alpha-17-alkylated steroid, its toxicity to the liver is low. Studies have shown that taking oxandrolone in a daily dose of 20 mg for 12 weeks had a negligible effect on an increase in the activity of liver enzymes. Being a derivative of dihydrotestosterone, oxandrolone does not aromatize. It also has no significant effect on the production of testosterone in the body (does not inhibit the axis of the hypothalamus-pituitary-testes) at doses below 20 mg. At high doses, the body responds with a natural reduction in the production of luteinizing hormone, as occurs with too high levels of endogenous testosterone. This in turn inhibits further stimulation of Leydig cells in the testes, which can cause their atrophy. After using the drug at a dose of 20 mg per day for 12 weeks, the production of testosterone was suppressed by 67%. In a randomized, double-blind study, patients with burns of 40% of the total body surface area were selected to receive standard burn treatment plus oxandrolone with or without oxandrolone. Those taking oxandrolone have shown improved tissue composition, muscle preservation and reduced hospital stay
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